Bill Ackman Calls AI’s Rare-Disease Breakthrough ‘Incredible’ After Model Finds Drug Combination for Dying Patient

On Wednesday, Pershing Square CEO Bill Ackman highlighted a case in which AI helped identify an untried drug combination for a rare-disease patient who had been sent to hospice. AI Finds New Treatment Path for Rare Disease Ackman on Wednesday shared a 2025 New York Times report on X about a 37-year-old man with POEMS syndrome, a rare blood disorder, whose condition had deteriorated to the point that he was being sent to hospice.

An AI system analyzed thousands of existing medicines and identified a combination that no one had previously tried for his condition. The patient reportedly responded within a week and later went into remission following a stem cell transplant.

"Incredible," Ackman wrote while sharing the report. Incredible.

co/T8Mf2yK8Ku— Bill Ackman (@BillAckman) September 23, 2026 The case highlights one potential application of AI in medicine — drug repurposing, where existing medicines are analyzed for possible uses against diseases they were not originally developed to treat. 6.

6’s medical responses than in responses written by physicians. In March, Eli Lilly & Co.

75 billion deal to bring AI-developed drugs from Hong Kong-based Insilico Medicine to the global market. Previously, Microsoft Corp.

(NASDAQ:MSFT) AI CEO Mustafa Suleyman also identified health care as a major AI opportunity. Microsoft and Mayo Clinic have partnered to develop a health care-focused AI model using Mayo’s clinical expertise and de-identified patient data.

S. health systems found clinical documentation was among the most successful uses, while more complex applications such as clinical risk prediction had lower reported success.

The survey identified immature technology, financial concerns and regulatory uncertainty as major barriers to broader adoption.

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